GLUTATHIONE
Glutathione (GSH) is a tripeptide composed of L-glutamic acid, L-cysteine, and glycine, naturally synthesized in nearly all eukaryotic cells. It functions as one of the body’s most important endogenous antioxidants and is essential for maintaining redox balance, detoxification, and immune defense at the cellular level.
In scientific research, Glutathione is studied for its involvement in oxidative stress regulation, cellular detoxification mechanisms, mitochondrial function, and redox-sensitive signaling pathways. Because of its central role in maintaining intracellular redox homeostasis, it serves as a key research molecule in fields including cellular aging, toxicology, immunology, and metabolic biochemistry.
Price range: $40.00 through $55.00
Oxidative Stress and Redox Homeostasis
- Glutathione is a principal intracellular antioxidant that helps regulate reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels.
- Enables research into redox signaling, oxidative damage mitigation, and cellular defense mechanisms under stress conditions.
- Acts as a cofactor for antioxidant enzymes such as glutathione peroxidase (GPx) and glutathione reductase (GR), making it a core reagent in oxidative stress studies.
Detoxification and Xenobiotic Metabolism
- Studied for its role in conjugation reactions with electrophilic compounds and toxins through glutathione-S-transferases (GSTs).
- Provides a model for examining cellular detoxification, hepatic clearance pathways, and phase II metabolic reactions.
Mitochondrial Function and Energy Regulation
- Used in research exploring how mitochondrial redox balance influences ATP synthesis, mitochondrial permeability, and apoptotic signaling.
- Assists in studying the relationship between oxidative stress and mitochondrial dysfunction in aging and metabolic disorders.
Immune Function and Cellular Defense
- Investigated for its effects on T-cell activation, cytokine regulation, and immune response modulation in vitro.
- Provides a biochemical model for understanding redox-sensitive immune signaling and inflammatory control mechanisms.
Protein Folding and Thiol–Disulfide Exchange
- Functions as a redox buffer in the endoplasmic reticulum (ER), assisting in protein folding, S-glutathionylation, and disulfide bond formation.
- Enables examination of protein stability and redox-dependent post-translational modifications.
Cellular Aging and Longevity Research
- Widely used in studies investigating the decline of antioxidant defenses with age, telomere attrition, and cellular senescence.
- Offers insights into how glutathione depletion correlates with oxidative DNA damage and mitochondrial degradation.
Neurological and Metabolic Pathway Studies
- Utilized to study glutathione’s role in neuronal protection, neuroinflammation, and energy metabolism in pre-clinical models.
- Helps elucidate metabolic cross-talk between glutathione, NADPH, and other redox cofactors.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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