IGF-1 DES
IGF-1 DES (1–3) is a shortened analog of human Insulin-Like Growth Factor-1 (IGF-1), consisting of 67 amino acids instead of 70. It lacks the first three amino acids (Gly-Pro-Glu) at the N-terminus of native IGF-1, resulting in enhanced receptor binding affinity and reduced interaction with IGF Binding Proteins (IGFBPs).
These structural modifications allow IGF-1 DES to demonstrate superior local potency and shorter systemic half-life, making it ideal for in-vitro and pre-clinical research involving cellular proliferation, regeneration, tissue growth, and protein synthesis signaling.
In experimental settings, IGF-1 DES is widely utilized to explore muscle cell differentiation, wound healing, neuroprotection, and anabolic mechanisms through its influence on the IGF-1 receptor (IGF-1R) and downstream PI3K/Akt and MAPK signaling cascades.
$60.00
Cellular Growth and Proliferation Studies
- Demonstrates higher potency in stimulating cellular proliferation and differentiation than native IGF-1 due to increased IGF-1R activation.
- Used to examine mitogenic and anabolic signaling pathways in myoblasts, fibroblasts, and epithelial cells.
- Supports research into cell cycle regulation, growth factor signaling, and tissue regeneration dynamics.
Muscle Growth and Regeneration Models
- Enables study of muscle hypertrophy, protein synthesis, and tissue repair via PI3K/Akt/mTOR pathway activation.
- Commonly employed alongside GH secretagogues (e.g., CJC-1295 or GHRP-6) to investigate synergistic anabolic signaling.
- Provides a framework for exploring muscle satellite cell activation and myonuclear proliferation.
Protein Synthesis and Anabolic Pathways
- Acts as a potent stimulator of protein transcription and translation in various cell types.
- Used in pre-clinical studies to assess IGF-1–dependent anabolic responses, including ribosomal activation and mTOR signaling modulation.
Wound Healing and Tissue Repair Research
- IGF-1 DES has been studied for its ability to accelerate fibroblast migration, collagen deposition, and angiogenesis in wound-healing models.
- Supports examination of growth factor-mediated recovery in skin, tendon, and connective tissue repair systems.
Neuroprotective and Neural Regeneration Research
- Investigated in neuronal models for promoting neurite outgrowth, synaptic recovery, and oxidative damage resistance.
- Provides insight into IGF-1R-mediated neurotrophic signaling, axon regeneration, and cell survival mechanisms in neurobiology research.
Localized Anabolic and Regenerative Effects
- The short half-life and enhanced receptor affinity allow IGF-1 DES to act locally and transiently, mimicking physiological pulsatile growth factor release.
- Ideal for studying site-specific cellular responses and localized growth factor kinetics without prolonged systemic activity.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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