SEMAX
SEMAX is a synthetic heptapeptide (sequence: Met-Glu-His-Phe-Pro-Gly-Pro) derived from a fragment of adrenocorticotropic hormone (ACTH 4–10). It was originally developed as a neuroactive research peptide to study neuroprotection, cognitive modulation, and neurotrophic signaling mechanisms without hormonal side effects.
In pre-clinical and in-vitro studies, SEMAX has been observed to influence brain-derived neurotrophic factor (BDNF) expression, dopaminergic and cholinergic signaling, and oxidative stress responses. These properties make it a valuable model compound for exploring neuroregeneration, synaptic plasticity, and stress adaptation pathways in the central nervous system.
$31.00
Neuroprotection and Neuronal Survival Research
- SEMAX has been studied for its ability to support neuronal survival and function in environments of oxidative or ischemic stress.
- Provides a model for exploring neuroprotective signaling, apoptotic pathway inhibition, and cellular recovery mechanisms in cortical and hippocampal neurons.
- Useful for studying mitochondrial stability, free radical modulation, and neuroinflammatory responses.
Brain-Derived Neurotrophic Factor (BDNF) Expression
- In research settings, SEMAX has been shown to upregulate BDNF and NGF (nerve growth factor), both critical for neurogenesis and synaptic plasticity.
- Facilitates the study of peptide-induced neurotrophin expression and cell signaling cascades associated with cognitive function and memory formation.
- Used to investigate the CREB and ERK1/2 pathways, which are involved in neuronal adaptation and long-term potentiation (LTP).
Cognitive and Memory Research
- SEMAX’s influence on cholinergic and dopaminergic systems makes it a valuable research tool for studying learning, focus, and attention mechanisms.
- Researchers use SEMAX to evaluate neurotransmitter modulation, synaptic density, and neuronal connectivity under various experimental conditions.
- Helps to explore cognitive resilience and neural efficiency in stress and fatigue models.
Stress and Adaptation Mechanisms
- SEMAX has been examined for its role in stress adaptation, anti-inflammatory regulation, and hypothalamic-pituitary axis (HPA) balance in laboratory settings.
- Provides insights into peptide-based homeostatic control and the body’s molecular response to environmental or psychological stressors.
Cerebrovascular and Oxygenation Studies
- Pre-clinical data suggest SEMAX may influence cerebral blood flow regulation, microvascular tone, and neuronal oxygen utilization.
- Enables the study of peptide effects on cerebrovascular signaling, endothelial nitric oxide synthesis, and tissue perfusion during oxidative stress.
Neuroregeneration and Plasticity Models
- SEMAX provides a platform for studying axon sprouting, dendritic remodeling, and synapse reformation in neural injury and recovery research.
- Aids in analyzing neurorestorative processes following cellular or oxidative insult in controlled laboratory settings.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.
Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.
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