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SERMORELIN

SERMORELIN

Sermorelin acetate (also known as GRF 1–29 or Growth Hormone–Releasing Factor 1–29 amide) is a synthetic peptide analogue of the endogenous Growth Hormone–Releasing Hormone (GHRH) produced by the hypothalamus. It represents the first 29 amino acids of the natural GHRH(1–44) sequence — the minimal biologically active fragment responsible for binding and activating GHRH receptors on anterior pituitary somatotrophs.

By mimicking the physiological function of native GHRH, Sermorelin stimulates the hypothalamic–pituitary–somatotropic axis, leading to a pulsatile release of endogenous growth hormone (GH). This makes Sermorelin a valuable research peptide for studying GH regulation, endocrine feedback loops, pituitary function, and metabolic mechanisms associated with growth and repair.

Price range: $45.00 through $98.00

$45.00
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$36.00 (20% off)
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Sermorelin acetate (also known as GRF 1–29 or Growth Hormone–Releasing Factor 1–29 amide) is a synthetic peptide analogue of the endogenous Growth Hormone–Releasing Hormone (GHRH) produced by the hypothalamus. It represents the first 29 amino acids of the natural GHRH(1–44) sequence — the minimal biologically active fragment responsible for binding and activating GHRH receptors on anterior pituitary somatotrophs. By mimicking the physiological function of native GHRH, Sermorelin stimulates the hypothalamic–pituitary–somatotropic axis, leading to a pulsatile release of endogenous growth hormone (GH). This makes Sermorelin a valuable research peptide for studying GH regulation, endocrine feedback loops, pituitary function, and metabolic mechanisms associated with growth and repair.
Property
Specification
Peptide Type:
Synthetic GHRH analogue
Sequence (1–29):
H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Length:
29 amino acids
Molecular Formula:
C₁₅₂H₂₅₂N₄₄O₄₂S
Molecular Weight:
~3357.9 Da
Structure Type:
Linear amidated peptide (C-terminal amide)
Mechanistic Target:
Growth Hormone–Releasing Hormone (GHRH) receptor
Mode of Action:
Binds GHRH receptor → Activates adenylate cyclase → Increases cAMP → GH release
Solubility:
Soluble in water, PBS, and dilute acidified buffers
Storage:
≤ –20°C, protected from light and moisture

Structural Highlights:

  • Active Core Fragment: Sermorelin contains the full receptor-binding region of GHRH (residues 1–29), which maintains full agonist activity.
  • C-terminal Amidation: Enhances stability, prevents rapid enzymatic degradation, and extends biological half-life.
  • Mechanistic Action: Induces GH pulse secretion through the physiological GHRH–GH–IGF-1 pathway.
  • Receptor Selectivity: Selectively activates GHRH receptors in pituitary somatotroph cells without directly stimulating GH release (unlike GHRP analogues).

Sermorelin is a well-established research peptide in endocrine, metabolic, and age-related biology studies. It is commonly used to explore the regulation of growth hormone secretion, metabolic homeostasis, and pituitary responsiveness.

Endocrine and Growth Hormone Axis Research

  • Potently stimulates endogenous GH secretion through natural hypothalamic–pituitary signaling.
  • Enhances IGF-1 synthesis via GH-mediated hepatic pathways.
  • Valuable for mapping the feedback relationship between GH, GHRH, somatostatin, and IGF-1 in preclinical systems.

Metabolic Regulation and Body Composition Studies

  • Promotes lipolysis and fat metabolism through GH-induced mechanisms.
  • Supports studies into protein synthesis, lean mass preservation, and cellular repair.
  • Demonstrates metabolic improvements in research models of obesity and insulin resistance.

Pituitary and Neuroendocrine Research

  • Allows investigation into pituitary somatotroph function and receptor dynamics.
  • Useful for studying GH pulsatility, age-related declines in GH output, and neuroendocrine adaptation.
  • Serves as a model agonist for testing GHRH receptor modulators or feedback inhibitors.

Cognitive and Cellular Recovery Models

  • Indirectly enhances GH-IGF-1–mediated neural support and cellular regeneration mechanisms in research.
  • Used in neuroendocrine studies to explore GH’s influence on neuroplasticity, mitochondrial function, and cognitive metabolism.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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