SLU-PP-332
SLU-PP-332 is a synthetic small-molecule PPARδ/β (Peroxisome Proliferator-Activated Receptor delta/beta) agonist designed to modulate cellular metabolism, mitochondrial function, and energy expenditure. Developed at Saint Louis University as part of an emerging class of exercise-mimetic metabolic activators, SLU-PP-332 is being studied for its ability to increase fatty acid oxidation, enhance mitochondrial biogenesis, and shift energy utilization toward oxidative metabolism in muscle and metabolic tissues.
Through potent and selective activation of PPARδ, SLU-PP-332 promotes gene expression patterns similar to those induced by endurance exercise — including upregulation of oxidative phosphorylation (OXPHOS) pathways, lipid utilization, and thermogenic activity. This makes it an important tool for exploring obesity, type 2 diabetes, lipid metabolism, and muscle endurance in research settings.
Price range: $85.00 through $110.00
Structural Highlights
- Core Scaffold: Small heteroaromatic framework optimized for nuclear receptor affinity and selectivity toward PPAR-δ over PPAR-α or PPAR-γ.
- Functional Moieties: Designed to engage the ligand-binding pocket of PPAR-δ, stabilizing co-activator recruitment complexes (PGC-1α–related).
- Downstream Pathway Activation: Enhances expression of genes responsible for fatty acid transport (CPT1, CD36), β-oxidation, and mitochondrial respiration.
SLU-PP-332 is increasingly used as a research probe compound for studying metabolic regulation, exercise mimetics, lipid metabolism, mitochondrial health, and energy expenditure. Its high selectivity and potency toward PPARδ make it a valuable model molecule for exploring how nuclear receptor activation can modulate systemic metabolism.
Metabolic Regulation and Energy Expenditure
- Potently activates PPARδ-dependent transcription, leading to enhanced fatty acid oxidation and mitochondrial ATP generation.
- Shifts metabolic preference from glucose toward lipid utilization, mimicking fasting and endurance-exercise states.
- Promotes oxidative muscle fiber formation and increases metabolic endurance in preclinical models.
Mitochondrial Biogenesis and Function
- Upregulates PGC-1α, NRF1, and TFAM, key regulators of mitochondrial replication and respiratory chain capacity.
- Increases mitochondrial density and oxygen consumption rate in cell-based metabolic assays.
- Facilitates research into mitochondrial diseases, cellular energy management, and age-related energy decline.
Lipid and Glucose Metabolism
- Enhances lipid clearance and triglyceride metabolism in hepatic and skeletal muscle models.
- Reduces lipid accumulation and inflammatory signaling associated with high-fat diets in preclinical studies.
- Improves glucose utilization efficiency under metabolic stress conditions.
Exercise-Mimetic and Endurance Research
- Reproduces gene expression signatures observed during aerobic endurance training.
- Increases oxidative muscle fiber composition (Type I) and reduces reliance on glycolytic energy systems.
- Supports investigation into exercise-induced metabolic adaptation and skeletal muscle fatigue resistance.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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