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TB-500

TB-500

TB-500 is a synthetic peptide fragment derived from the naturally occurring Thymosin Beta-4 (Tβ4) protein, a 43-amino-acid peptide found in almost all mammalian cells. In pre-clinical and in-vitro studies, TB-500 has been widely examined for its ability to enhance cellular migration, promote angiogenesis, modulate inflammation, and accelerate tissue repair.

TB-500’s biological activity is primarily attributed to its regulation of G-actin polymerization, a process critical to cell movement, structure, and differentiation. Because of this, TB-500 is frequently used in research focused on wound healing, muscle and tendon recovery, angiogenic signaling, and cytoskeletal organization.

Price range: $40.00 through $54.00

$40.00
1 - 2
$32.00 (20% off)
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$28.00 (30% off)
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$24.00 (40% off)
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TB-500 is a synthetic peptide fragment derived from the naturally occurring Thymosin Beta-4 (Tβ4) protein, a 43-amino-acid peptide found in almost all mammalian cells. In pre-clinical and in-vitro studies, TB-500 has been widely examined for its ability to enhance cellular migration, promote angiogenesis, modulate inflammation, and accelerate tissue repair. TB-500’s biological activity is primarily attributed to its regulation of G-actin polymerization, a process critical to cell movement, structure, and differentiation. Because of this, TB-500 is frequently used in research focused on wound healing, muscle and tendon recovery, angiogenic signaling, and cytoskeletal organization.
Property
Specification
Peptide Name:
TB-500 (Thymosin Beta-4 Fragment)
Sequence:
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Glu-Lys-Phe-Asp-Lys-NH₂
Amino Acid Length:
43
Molecular Formula:
C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight:
~4963.5 Da
CAS Number:
77591-33-4
Peptide Type:
Synthetic thymosin peptide analog
Structure Type:
Linear polypeptide (acetylated N-terminus, amidated C-terminus)
Form:
Lyophilized white/off-white powder
Purity:
99 % (HPLC verified)
Solubility:
Soluble in sterile water, PBS, or 0.1 % acetic acid for laboratory reconstitution
Storage:
−20 °C, protected from light and moisture
Stability:
Stable for up to 24 months under recommended storage conditions

The following research topics are based on pre-clinical and in-vitro studies.
TB-500 is not approved for human or veterinary use and is provided strictly for laboratory research.

Cellular Migration and Actin Regulation Studies

  • TB-500 plays a central role in G-actin (globular actin) binding and polymerization, crucial for cell motility and structural organization.
  • Used in studies investigating cellular migration, tissue remodeling, and cytoskeletal reorganization.
  • Provides a model for analyzing cellular response to injury and structural regeneration.

Angiogenesis and Vascular Growth Research

  • Demonstrated in pre-clinical models to influence endothelial cell migration, capillary formation, and vascular stability.
  • Enables exploration of angiogenic signaling, oxygenation pathways, and vascular remodeling mechanisms.
  • Often paired with BPC-157 or AICAR in studies related to vascular regeneration and tissue perfusion.

Muscle and Connective Tissue Regeneration Studies

  • TB-500 has been shown to enhance myoblast differentiation and fibroblast activity, supporting research on skeletal muscle recovery and connective tissue repair.
  • Commonly used in pre-clinical models to study myocardial repair, tendon regeneration, and muscle hypertrophy.
  • Provides insight into peptide-mediated anabolic signaling in soft tissue biology.

Anti-Inflammatory and Immune Modulation Research

  • Known to affect cytokine balance, helping researchers understand immune response regulation during tissue recovery.
  • Used in studies focusing on NF-κB inhibition, macrophage polarization, and anti-inflammatory peptide pathways.
  • Facilitates analysis of immune-mediated wound healing and cell migration under inflammatory stress.

Wound Healing and Tissue Remodeling Studies

  • Provides a valuable model for epithelial cell migration, collagen deposition, and extracellular matrix (ECM) realignment.
  • Studied for its potential to support keratinocyte regeneration and angiogenic tissue repair in pre-clinical wound-healing assays.
  • Offers researchers insight into biochemical and cellular cascades responsible for post-injury tissue recovery.

Cardiovascular and Ischemic Research

  • Utilized in laboratory models to study myocardial cell regeneration and tissue response under hypoxic conditions.
  • Supports research into cardiac myocyte migration, angiogenic remodeling, and microvascular reoxygenation following ischemic insult.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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