TESEMORELIN
Tesamorelin (also known as TH9507) is a synthetic peptide analogue of human Growth Hormone–Releasing Hormone (GHRH), engineered to stimulate the pituitary gland’s natural production and release of growth hormone (GH). It consists of 44 amino acids that replicate the bioactive region of endogenous GHRH (1–44), but with a key modification — the substitution of trans-3-hexenoic acid (TFA) at the N-terminus — which significantly enhances the molecule’s stability and biological half-life.
Tesamorelin functions by binding to GHRH receptors on pituitary somatotroph cells, initiating a cascade that increases cyclic AMP (cAMP) and intracellular calcium, leading to a pulsatile release of growth hormone.
This makes Tesamorelin a powerful research compound for studies involving GH/IGF-1 axis regulation, lipid metabolism, body composition, and neuroendocrine signaling.
Price range: $49.00 through $95.00
Structural Highlights:
- Modified GHRH(1–44) Analogue: Preserves full receptor-binding affinity while enhancing molecular stability.
- N-terminal Lipophilic Substitution: Provides protection against enzymatic degradation (especially by DPP-IV) and improves bioavailability.
- Amidated C-Terminus: Adds conformational stability and increases plasma half-life.
- Mechanistic Target: GHRH receptor (class B GPCR) expressed on pituitary somatotrophs.
Tesamorelin is extensively utilized in endocrine and metabolic research as a selective GHRH receptor agonist. It serves as a valuable tool for studying growth hormone dynamics, lipolysis, adipose metabolism, and IGF-1 signaling.
Growth Hormone Axis Regulation
- Stimulates endogenous GH secretion by mimicking natural GHRH activity.
- Increases circulating insulin-like growth factor 1 (IGF-1) levels through GH-mediated hepatic synthesis.
- Useful for exploring GH pulsatility, pituitary responsiveness, and age-related GH decline.
Body Composition and Fat Metabolism
- Promotes lipolysis and reduction of visceral adipose tissue in research models.
- Enhances lipid mobilization and fatty acid oxidation through GH-induced metabolic pathways.
- Serves as a model for studying adipose tissue regulation and energy homeostasis.
Cellular and Metabolic Effects
- Facilitates protein synthesis, cell proliferation, and mitochondrial activation in GH-responsive tissues.
- Increases nitrogen retention and amino acid uptake in muscle and liver cells.
- Allows investigation into IGF-1–dependent growth, repair, and recovery processes.
Cognitive and Neuroendocrine Research
- GH and IGF-1 have been shown to play roles in neurogenesis and synaptic plasticity.
- Tesamorelin is used in research to explore GH-mediated neuroprotective mechanisms and metabolic-cognitive interactions.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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