ARA-290
ARA-290, also known as Cibinetide, is an 8-amino-acid synthetic peptide derived from the B-helix region of erythropoietin (EPO). It was engineered to retain the tissue-protective and anti-inflammatory properties of EPO while eliminating its erythropoietic (red blood cell–stimulating) activity.
In pre-clinical and in-vitro research, ARA-290 has been shown to activate the innate repair receptor (IRR) — a heterodimer composed of EPOR (erythropoietin receptor) and CD131 (β common receptor) — leading to anti-inflammatory signaling, neuroprotection, and tissue regeneration. This selectivity makes it a valuable model compound for studying immune regulation, nerve injury repair, chronic pain mechanisms, and metabolic inflammation.
Used extensively in pre-clinical and in-vitro research, Acetic Acid (0.6%) supports consistent peptide handling by maintaining molecular integrity, minimizing hydrolytic degradation, and promoting uniform solubilization of amino acid chains.
$50.00
Neuroprotective and Nerve Regeneration Studies
- Demonstrated to protect neurons and glial cells under oxidative or inflammatory stress in pre-clinical models.
- Enhances nerve regeneration, axon sprouting, and synaptic repair following mechanical or metabolic injury.
- Used to study peptide-mediated neurotrophic signaling and nerve recovery pathways.
Anti-Inflammatory and Cytokine Regulation Research
- Activates the Innate Repair Receptor (EPOR/CD131 complex) to reduce pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β.
- Provides a model for inflammation modulation in tissue injury, ischemia, and autoimmune response research.
- Distinctly non-erythropoietic, allowing targeted study of EPO-derived anti-inflammatory mechanisms.
Endothelial and Tissue Protection Studies
- Enhances microvascular stability, reduces endothelial permeability, and promotes angiogenic balance under stress conditions.
- Serves as a model for ischemic tissue protection and vascular peptide signaling.
- Investigated for its potential role in reducing reperfusion injury and oxidative cellular damage.
Metabolic and Insulin Sensitivity Research
- Studied for its ability to improve insulin sensitivity and reduce metabolic inflammation in cell and animal models.
- Provides a system for analyzing immune-metabolic cross-talk and peptide-based metabolic regulation.
Chronic Pain and Neuropathy Research
- Investigated in models of small fiber neuropathy for its potential to support nerve function restoration.
- Useful in exploring peptide-mediated analgesic signaling through cytokine modulation and nerve repair pathways.
Cellular Stress and Oxidative Damage Studies
- Shown in vitro to reduce oxidative stress and support mitochondrial stability under inflammatory load.
- Provides a model for peptide protection mechanisms involving NF-κB suppression and anti-apoptotic signaling.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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