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PT 141

PT 141

PT-141 (Bremelanotide) is a synthetic heptapeptide derived from the melanocortin peptide family, specifically designed as an analog of α-melanocyte-stimulating hormone (α-MSH). In pre-clinical research, PT-141 is used to study central melanocortin pathways related to neuroendocrine activity, sexual function signaling, vasodilation, behavioral responses, and hypothalamic regulation.

Unlike peripheral vasodilators, PT-141 acts directly through MC3R and MC4R receptor activation within the central nervous system, making it valuable in controlled studies examining arousal signaling, metabolic processes, appetite modulation, and neurohormonal pathways.

$34.00

$34.00
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$27.20 (20% off)
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$23.80 (30% off)
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$20.40 (40% off)
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PT-141 (Bremelanotide) is a synthetic heptapeptide derived from the melanocortin peptide family, specifically designed as an analog of α-melanocyte-stimulating hormone (α-MSH). In pre-clinical research, PT-141 is used to study central melanocortin pathways related to neuroendocrine activity, sexual function signaling, vasodilation, behavioral responses, and hypothalamic regulation. Unlike peripheral vasodilators, PT-141 acts directly through MC3R and MC4R receptor activation within the central nervous system, making it valuable in controlled studies examining arousal signaling, metabolic processes, appetite modulation, and neurohormonal pathways.
Property
Specification
Peptide Type:
Synthetic Growth Hormone–Releasing Hormone (GHRH) analogue
Peptide Length:
44 amino acids
Molecular Formula:
C₂₁₃H₃₇₂N₇₂O₆₇
Molecular Weight:
~5135.9 Da
Sequence (1–44):
H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Gln-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Structural Modification:
N-terminal modification with trans-3-hexenoic acid (TFA) to prevent DPP-IV degradation
Mechanism of Action:
Binds GHRH receptor → Activates adenylate cyclase → Stimulates GH release
Solubility:
Soluble in sterile water and most aqueous buffers
Storage:
≤ –20°C (protected from light and moisture)

The following research interests are based on pre-clinical and in-vitro studies only. PT-141 is not approved for human or veterinary use and is supplied exclusively for laboratory research.

Neuroendocrine & Melanocortin Pathway Research

  • PT-141 is widely used to investigate MC3R and MC4R activation in central hypothalamic circuits.
  • Supports research on neuropeptide signaling, hormonal response, and neuroendocrine regulation.
  • Useful in studies exploring neural mechanisms of arousal and behavioral activation.

Sexual Function & Arousal Mechanisms

  • Enables study of CNS-mediated arousal pathways independent of peripheral vascular effects.
  • Investigated in pre-clinical models for its influence on libido signaling and central melanocortin activation.
  • Provides a controlled research tool for examining sexual behavior neurobiology.

Vasodilation & Vascular Response Studies

  • Offers a model for studying neurovascular modulation through central receptor pathways.
  • Allows examination of blood-flow-related responses via melanocortin stimulation rather than nitric oxide pathways.
  • Supports research on cerebrovascular interactions in controlled environments.

Hormonal & Stress-Related Signaling

  • Studied for its interactions with neurohormonal networks and hypothalamic signaling cascades.
  • Provides insight into peptide-driven hormonal responses and CNS regulatory mechanisms.
  • Useful for exploring melanocortin involvement in stress and endocrine modulation.

Metabolic & Appetite Regulation Pathways

  • MC4R activity allows research into appetite suppression, caloric intake, and metabolic balance.
  • Supports studies on hypothalamic energy regulation and neuropeptide influence on metabolism.
  • Contributes to research models analyzing energy expenditure and neural metabolic control.

Inflammatory & Oxidative Stress Studies

  • Pre-clinical findings suggest possible roles in cytokine signaling modulation.
  • Useful for examining oxidative stress pathways and cellular resilience under experimental conditions.
  • Enables investigation into interactions between melanocortin receptors and inflammatory responses.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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