ADIPOTIDE
Adipotide (Prohibitin-Targeting Peptide 1 or FTPP) is a synthetic peptidomimetic compound designed for pre-clinical research exploring targeted apoptosis of white adipose tissue (WAT). It was originally developed to study vascular-targeted adipose reduction by inducing selective apoptosis in adipose tissue endothelial cells, leading to subsequent adipocyte atrophy in animal models.
Adipotide is composed of a homing peptide sequence (CKGGRAKDC) linked to a pro-apoptotic peptide motif (KLAKLAK₂). This dual-action structure enables targeted binding to prohibitin receptors on the surface of white adipose vasculature, followed by mitochondrial membrane disruption in endothelial cells.
In research contexts, Adipotide serves as a powerful model for investigating angiogenesis inhibition, adipose metabolism, energy homeostasis, and metabolic disorder mechanisms. It provides a novel approach to studying selective fat metabolism without acting on central appetite pathways, making it valuable in metabolic and vascular biology research.
Revacta Labs provides high-purity, research-grade Adipotide synthesized under GMP-aligned peptide synthesis standards. Each batch is confirmed by HPLC and Mass Spectrometry analysis with ≥99% purity, and a Certificate of Analysis (COA) is included for transparency and reproducibility.
$50.00
The following research applications reflect pre-clinical and in-vitro studies only.
Adipotide is not approved for human or veterinary use and is provided strictly for controlled laboratory research.
1. Targeted Adipose Tissue Apoptosis Research
- Designed to target prohibitin receptors located on the vasculature of white adipose tissue (WAT).
- Enables selective study of adipose tissue regression through endothelial apoptosis rather than central appetite modulation.
- Serves as a model for adipose vascular biology and angiogenesis inhibition research.
2. Energy Balance and Metabolic Signaling Studies
- Provides a research framework for examining lipid metabolism, fat mobilization, and systemic energy homeostasis following adipose tissue reduction.
- Used in pre-clinical studies exploring metabolic syndrome, insulin sensitivity, and glucose tolerance.
- Supports investigation into the metabolic consequences of adipose remodeling and its relationship with endocrine signaling.
3. Vascular Targeting and Anti-Angiogenic Mechanisms
- Adipotide’s vascular homing domain (CKGGRAKDC) allows targeted delivery to endothelial cells of adipose vasculature, helping researchers explore vasculature remodeling and capillary regression mechanisms.
- Enables mapping of angiogenic vs. anti-angiogenic balance in adipose microenvironments.
4. Mitochondrial and Apoptotic Pathway Studies
- The pro-apoptotic sequence (KLAKLAK₂) in Adipotide facilitates the study of mitochondrial membrane disruption, cytochrome c release, and caspase cascade activation in endothelial cells.
- Provides an effective in-vitro model for selective apoptosis signaling, mitochondrial stress, and cellular metabolic shutdown.
5. Obesity and Adiposity Research Models
- Used in animal research to assess the effects of selective adipose tissue reduction on body composition, organ weight, and systemic metabolism.
- Enables distinction between adipose vascular targeting and CNS appetite-based mechanisms, supporting mechanistic metabolic studies.
6. Combination and Comparative Research
- Studied in conjunction with AMPK activators (AICAR), GLP-1 analogs (Semaglutide), and GH secretagogues (CJC-1295, Ipamorelin) to explore synergistic effects on energy balance and cellular metabolism.
- Provides comparative data for multi-pathway metabolic modulation and tissue-specific peptide targeting.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.
Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.
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