AICAR
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic adenosine monophosphate (AMP) analog widely utilized in metabolic and biochemical research for its ability to activate AMP-activated protein kinase (AMPK) — a critical enzyme regulating cellular energy balance.
AMPK serves as a master metabolic regulator that senses intracellular energy levels and promotes catabolic pathways to restore ATP homeostasis. In scientific research, AICAR is used to investigate metabolic signaling, mitochondrial biogenesis, glucose transport, lipid oxidation, and skeletal muscle metabolism.
Because of its ability to mimic the effects of exercise and caloric restriction at the molecular level, AICAR has become a cornerstone compound in metabolic physiology, endocrinology, and sports science research.
$54.00
1. AMPK Pathway Activation Studies
- AICAR acts as an AMP analog, directly activating AMP-activated protein kinase (AMPK), a key metabolic enzyme that monitors cellular energy status.
- Used extensively in research to explore energy sensing, ATP/AMP ratios, and metabolic reprogramming in eukaryotic cells.
- Provides a model for pharmacological activation of AMPK independent of exercise or nutrient depletion.
2. Glucose Uptake and Insulin Sensitivity Research
- Studied for its role in enhancing GLUT4 translocation and glucose uptake in skeletal muscle and adipose cells.
- Enables research into insulin signaling, metabolic flexibility, and glucose homeostasis under controlled conditions.
- Valuable for investigating exercise-mimetic effects in energy metabolism studies.
3. Fatty Acid Oxidation and Lipid Metabolism
- Activation of AMPK by AICAR inhibits acetyl-CoA carboxylase (ACC), promoting fatty acid oxidation and reducing lipid synthesis.
- Supports studies in hepatic lipid metabolism, adipocyte signaling, and lipid droplet mobilization.
- Provides insights into mitochondrial energy utilization and lipid regulation pathways.
4. Mitochondrial Biogenesis and Cellular Energy Efficiency
- AICAR has been used in pre-clinical studies to stimulate PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) — a master regulator of mitochondrial biogenesis.
- Enables research into cellular endurance, bioenergetic efficiency, and oxidative capacity of muscle and neuronal cells.
- Serves as a biochemical model for aerobic capacity enhancement via AMPK-mediated pathways.
5. Skeletal Muscle and Exercise Physiology Studies
- Employed as an experimental compound for simulating exercise-induced metabolic adaptation at the molecular level.
- Provides a controlled model for understanding muscle fiber endurance, glycogen utilization, and metabolic reprogramming.
- Aids in identifying peptide–energy pathway cross-talk, especially in studies involving CJC-1295, GH secretagogues, or BPC-157 combinations.
6. Cardiovascular and Ischemia Research
- AICAR has been studied for its ability to improve myocardial energy metabolism by promoting ATP regeneration under low-oxygen conditions.
- Provides researchers with a model to explore AMPK-driven cytoprotection, ischemic preconditioning, and vascular energy signaling.
7. Cellular Stress and Aging Mechanisms
- Used to examine how AMPK activation impacts oxidative stress, autophagy, and cellular senescence.
- Offers insights into anti-aging metabolic responses by modulating mTOR, SIRT1, and ULK1 pathways in cellular models.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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