CJC-1295 (No DAC)
CJC-1295 (No DAC)is a synthetic analogue of Growth Hormone–Releasing Hormone (GHRH 1–44), engineered to enhance pituitary stimulation and endogenous growth hormone (GH) release without the use of a Drug Affinity Complex (DAC) linker.
This version retains the active GHRH 1–29 fragment, responsible for binding and activating GHRH receptors on somatotroph cells within the anterior pituitary, thereby inducing natural GH pulse secretion and IGF-1 elevation.
Unlike CJC-1295 with DAC, the “No DAC” form is short-acting — producing a rapid, pulsatile release of growth hormone that closely mimics natural physiological GH rhythm.
It is a valuable model peptide for investigating short-term endocrine modulation, GH/IGF-1 axis dynamics, and feedback mechanisms of somatotropic signaling in laboratory settings.
Price range: $59.00 through $78.00
Structural Highlights:
- Active Core Fragment: Retains the biologically active 1–29 region of human GHRH, the minimum sequence required for full receptor activation.
- Modified Stability: Incorporates four amino-acid substitutions to resist enzymatic degradation, improving peptide half-life and potency relative to native GHRH.
- No DAC Modification: Lacks the Drug Affinity Complex linker, resulting in a natural, short-acting GH pulse rather than a continuous GH elevation.
- Mechanistic Specificity: Directly activates the GHRH receptor, stimulating cyclic AMP (cAMP) production and subsequent GH synthesis and release.
Mechanism of Action
CJC-1295 (No DAC) acts as a selective agonist for the GHRH receptor, located on pituitary somatotrophs.
Upon binding, it activates the adenylate cyclase → cAMP → PKA signaling cascade, leading to transcriptional activation of GH mRNA and vesicular release of growth hormone into systemic circulation.
Because it lacks the DAC moiety, the peptide’s activity is short-lived, producing pulsatile GH spikes that emulate the body’s natural nocturnal secretion cycle, thus preserving physiological feedback inhibition by somatostatin and IGF-1.
CJC-1295 (No DAC) is widely used in preclinical and academic research to explore the acute regulation of the GH/IGF-1 axis, pituitary responsiveness, and metabolic effects of transient GH signaling.
Endocrine and GH Regulation Research
- Stimulates short-term GH release through direct pituitary receptor activation.
- Induces transient increases in IGF-1 production in hepatic tissue models.
- Useful for studying somatotropic feedback mechanisms, GHRH receptor dynamics, and hormonal rhythm synchronization.
Metabolic and Anabolic Studies
- Promotes lipolytic activity and fat metabolism via GH-mediated mechanisms.
- Enhances amino-acid transport, nitrogen retention, and protein synthesis in vitro.
- Valuable for exploring the metabolic effects of pulsatile GH exposure versus sustained GH release.
Neuroendocrine and Aging Research
- Provides a short-acting model to study age-related GH decline and neuroendocrine rhythm regulation.
- Supports investigations into sleep-related GH pulses, pituitary desensitization, and GH-mediated repair pathways.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
Related Product
Disclaimer: For Research Use Only
All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.
Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.
Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.