CJC-1295 + GHRP-2
CJC-1295 + GHRP-2 is a synergistic dual-peptide combination designed for research into growth hormone (GH) axis regulation, pituitary stimulation, and metabolic physiology.
This blend unites two potent GH secretagogues that act on complementary pathways within the somatotropic endocrine system:
- CJC-1295 – a synthetic analogue of Growth Hormone–Releasing Hormone (GHRH 1–44) that binds to pituitary GHRH receptors, stimulating endogenous GH synthesis and release.
- GHRP-2 (Growth Hormone–Releasing Peptide-2) – a synthetic hexapeptide that activates the ghrelin receptor (GHSR-1a), enhancing GH pulse amplitude through a different intracellular signaling pathway.
When combined, these peptides provide a robust model for studying dual-pathway growth hormone regulation, mimicking the body’s natural GH pulsatility while amplifying total GH output in controlled laboratory conditions.
$60.00
- CJC-1295 – a synthetic analogue of Growth Hormone–Releasing Hormone (GHRH 1–44) that binds to pituitary GHRH receptors, stimulating endogenous GH synthesis and release.
- GHRP-2 (Growth Hormone–Releasing Peptide-2) – a synthetic hexapeptide that activates the ghrelin receptor (GHSR-1a), enhancing GH pulse amplitude through a different intracellular signaling pathway.
Structural Highlights:
- CJC-1295: Activates GHRH receptors to promote long-acting GH synthesis and secretion. May include DAC modification for extended half-life through albumin binding.
- GHRP-2: Mimics endogenous ghrelin, triggering GH release through the phospholipase-C/inositol-trisphosphate (IP₃) pathway, independent of GHRH activity.
- Dual-Mechanism Synergy: Together, these peptides amplify both frequency and amplitude of GH pulses for a comprehensive model of somatotropic regulation.
Mechanism of Action
CJC-1295 Component:
Stimulates GHRH receptors on pituitary somatotroph cells, leading to activation of the adenylate cyclase → cAMP → PKA cascade, resulting in enhanced GH transcription and release.
With DAC modification, it binds to plasma albumin, prolonging biological activity up to 5–8 days in preclinical studies.
GHRP-2 Component:
Binds selectively to the GHSR-1a receptor, the same receptor activated by ghrelin, initiating a calcium-dependent exocytotic response that rapidly increases GH secretion.
Unlike earlier GHRPs, GHRP-2 exhibits high potency, minimal cortisol stimulation, and low desensitization rates.
The combined action of CJC-1295 and GHRP-2 enhances both spontaneous and stimulated GH release, offering an ideal dual model for exploring pituitary receptor synergy, feedback inhibition, and GH-IGF-1 endocrine signaling.
CJC-1295 + GHRP-2 has become a popular pairing in preclinical research on metabolic modulation, GH/IGF-1 regulation, and endocrine feedback balance.
Endocrine and Growth Hormone Regulation
- Dual activation of GHRH and ghrelin receptors, resulting in a multiplicative increase in GH pulse amplitude.
- Elevates IGF-1 levels in liver and systemic circulation models.
- Provides a versatile platform for exploring somatotropic feedback, pituitary desensitization, and circadian GH regulation.
Metabolic & Lipolytic Research
- Stimulates lipolysis, fatty-acid oxidation, and amino-acid transport in adipocyte and myocyte models.
- Supports studies into energy homeostasis, glucose metabolism, and nutrient partitioning.
- Enables examination of metabolic efficiency and lean mass preservation via GH-driven anabolic signaling.
Cellular Regeneration and Recovery
- Enhances GH-dependent cellular proliferation, protein synthesis, and collagen formation in tissue culture.
- Useful in neuroendocrine regeneration, wound-healing, and age-related GH decline research.
- Supports research into hypothalamic–pituitary resilience and stress adaptation mechanisms.
Feedback and Endocrine Crosstalk Models
- Allows investigation of GH, IGF-1, and somatostatin feedback loops.
- Models combined receptor activation and signal integration within the pituitary.
- Valuable for studying receptor cross-talk between the GHRH and ghrelin pathways.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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