CJC-1295 + GHRP-6
CJC-1295 + GHRP-6 is a dual-growth hormone secretagogue research formulation designed to model synergistic activation of the GH/IGF-1 axis through two distinct yet complementary mechanisms:
- CJC-1295 is a synthetic analogue of Growth Hormone–Releasing Hormone (GHRH 1–44), engineered to stimulate the pituitary gland’s somatotroph cells for endogenous GH synthesis and release.
- GHRP-6 (Growth Hormone–Releasing Peptide-6) is a hexapeptide ghrelin mimetic that activates growth hormone secretagogue receptors (GHSR-1a), promoting GH release through a separate intracellular signaling pathway.
Together, these peptides are used in preclinical and in vitro studies to explore dual-pathway GH stimulation, endocrine feedback dynamics, and metabolic regulation.
This combination provides a robust tool for examining pituitary responsiveness, energy balance, cellular repair, and neuroendocrine modulation.
$68.00
- CJC-1295 is a synthetic analogue of Growth Hormone–Releasing Hormone (GHRH 1–44), engineered to stimulate the pituitary gland’s somatotroph cells for endogenous GH synthesis and release.
- GHRP-6 (Growth Hormone–Releasing Peptide-6) is a hexapeptide ghrelin mimetic that activates growth hormone secretagogue receptors (GHSR-1a), promoting GH release through a separate intracellular signaling pathway.
Structural Highlights:
- CJC-1295: Modified analogue of GHRH that triggers GH synthesis through adenylate cyclase and cAMP-dependent PKA signaling. When conjugated with DAC, it binds to plasma albumin for prolonged stability and GH elevation.
- GHRP-6: Potent ghrelin mimetic that induces GH release by stimulating calcium mobilization through the phospholipase-C/IP₃ signaling pathway.
- Synergistic Mechanism: The combination of CJC-1295’s GHRH receptor activation and GHRP-6’s ghrelin receptor stimulation yields a comprehensive model of somatotropic synergy and endocrine crosstalk.
Mechanism of Action
CJC-1295 (GHRH Analogue):
Activates the GHRH receptor on pituitary somatotrophs, increasing cAMP and intracellular calcium, which drives GH gene transcription and vesicular release. DAC-modified variants extend half-life via covalent albumin binding, maintaining elevated GH levels for several days in preclinical models.
GHRP-6 (Ghrelin Mimetic):
Stimulates GHSR-1a receptors both in the hypothalamus and anterior pituitary. This receptor activation enhances GH release by amplifying GH pulse amplitude while minimizing cortisol or prolactin co-secretion.
When combined, CJC-1295 and GHRP-6 create a powerful dual-pathway model that elevates GH secretion both frequency-wise (CJC-1295) and amplitude-wise (GHRP-6), allowing researchers to explore pituitary receptor synergy and neuroendocrine regulation.
Endocrine and Growth Hormone Research
- Synergistic stimulation of GH release through simultaneous activation of GHRH and ghrelin pathways.
- Increases serum IGF-1 levels in preclinical models through enhanced GH output.
- Provides a reliable platform for studying pituitary receptor signaling, feedback inhibition, and hormone rhythm regulation.
Metabolic and Anabolic Studies
- Promotes lipolysis, protein synthesis, and amino-acid transport in vitro.
- Models metabolic homeostasis, energy expenditure, and body composition changes associated with GH regulation.
- Used to investigate metabolic dysfunction, insulin sensitivity, and fat oxidation pathways.
Cellular Repair and Regeneration
- Stimulates GH/IGF-1 pathways linked to tissue regeneration, collagen synthesis, and cell proliferation.
- Applied in studies of muscle cell recovery, connective tissue remodeling, and neuroendocrine repair.
- Supports research into age-related GH decline, oxidative stress adaptation, and pituitary rejuvenation.
Endocrine Feedback and Receptor Studies
- Enables exploration of dual receptor dynamics and cross-talk between the GHRH and GHSR signaling pathways.
- Useful in studying somatostatin-mediated feedback, GH pulsatility, and desensitization thresholds.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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