EPITHALON
Epitalon (also known as Epithalamin or Epithalon) is a synthetic tetrapeptide composed of the amino acid sequence Ala-Glu-Asp-Gly. It was first discovered and isolated by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a synthetic analogue of the naturally occurring pineal peptide Epithalamin.
Epitalon functions as a bioregulatory peptide that has been shown, in preclinical research, to influence telomerase activity, gene expression, and cellular longevity mechanisms.
It is primarily studied in the context of aging biology, oxidative stress, and circadian regulation, where it has been observed to modulate pineal function, enhance melatonin secretion, and promote genomic stability through effects on telomere elongation and DNA repair processes.
Epitalon’s compact four-amino-acid structure and its role in epigenetic regulation and antioxidant pathways make it a cornerstone molecule for modern gerontological, endocrine, and molecular longevity research.
Price range: $23.00 through $118.00
Structural Highlights:
- Minimalist Tetrapeptide: Epitalon’s short sequence allows rapid cellular permeability and high biochemical stability in aqueous systems.
- Endogenous Analogue: Synthetic mimic of Epithalamin, a naturally occurring pineal peptide complex known for anti-oxidative and endocrine-modulatory properties.
- Gene-Regulatory Role: Research indicates Epitalon interacts with chromatin and telomerase enzymes, influencing DNA repair and cell-cycle regulation.
- Biopeptide Simplicity: Despite its small size, Epitalon displays broad multi-system activity, from telomere maintenance to circadian synchronization.
Mechanism of Action
Epitalon’s primary mechanism in research appears to involve the upregulation of telomerase, the ribonucleoprotein enzyme responsible for maintaining and elongating telomeres at the ends of chromosomes. By restoring telomerase activity in aging cells, it supports DNA stability, genomic integrity, and replicative lifespan extension in vitro.
Epitalon is also shown in experimental models to modulate pineal gland function, particularly melatonin synthesis and circadian rhythm regulation, thereby influencing hormonal balance and oxidative homeostasis. At the molecular level, it appears to enhance expression of key antioxidant enzymes (such as superoxide dismutase) and modulate gene expression linked to stress resistance and apoptotic signaling pathways.
Cellular Longevity and Telomerase Research
- Stimulates telomerase reverse transcriptase (TERT) activity in somatic cell cultures.
- Promotes telomere elongation, counteracting replicative senescence in fibroblast and lymphocyte models.
- Serves as a tool for investigating genomic stability, telomere biology, and cellular aging processes.
Neuroendocrine and Pineal Function Studies
- Enhances melatonin secretion in pineal cell cultures and supports circadian gene expression normalization.
- Investigated as a biological clock modulator, aiding in studies of sleep–wake cycles, hormonal regulation, and aging neuroendocrinology.
- Demonstrates protective influence on pinealocyte activity and neuronal antioxidant defenses.
Oxidative Stress and Antioxidant Pathways
- Increases endogenous superoxide dismutase (SOD) and glutathione peroxidase activity in preclinical oxidative models.
- Reduces markers of lipid peroxidation and oxidative DNA damage.
- Valuable in experiments analyzing peptide antioxidants and redox homeostasis.
Gene Expression and Epigenetic Regulation
- Shown to affect transcriptional profiles related to apoptosis inhibition, DNA repair, and mitochondrial stability.
- Supports investigations into epigenetic modulation and protein synthesis regulation in aging cells.
- Used in comparative studies exploring bioregulatory peptide signaling in mammalian models.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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