FOXO4-DRI
FOXO4-DRI (also known as FOXO4-D-Retro-Inverso peptide) is a synthetic, D-amino acid peptide derived from the FOXO4 transcription factor—a member of the forkhead box O (FOXO) protein family involved in cell cycle regulation, stress response, and cellular aging.
In scientific research, FOXO4-DRI is studied for its ability to modulate interactions between FOXO4 and the tumor suppressor protein p53, a key regulator of cellular senescence and apoptosis. Through this pathway, FOXO4-DRI provides researchers with a tool for investigating cellular aging, DNA damage response, and senescence-associated secretory phenotype (SASP) mechanisms in vitro and in pre-clinical models.
$230.00
The following points describe potential research applications derived from pre-clinical literature.
FOXO4-DRI is not intended for human use and not approved by the FDA.
Cellular Senescence Studies
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- FOXO4-DRI has been used to study mechanisms that govern senescent cell survival by interfering with the FOXO4-p53 protein interaction, which may influence how cells respond to DNA damage or oxidative stress in vitro.
- Enables researchers to explore senolytic pathways and selective apoptosis of senescent cells in controlled models.
Aging and Longevity Mechanisms
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- Provides a platform to investigate the molecular biology of cellular aging, mitochondrial dysfunction, and genomic stability.
- Helps identify signaling cascades linking FOXO transcription factors with age-associated cell cycle arrest.
DNA Damage and Stress Response Research
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- Used to assess p53 activation, nuclear localization, and transcriptional activity in response to genotoxic stress.
- Supports research into cellular repair mechanisms, oxidative stress modulation, and apoptotic regulation.
Cancer Biology Investigations
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- Because FOXO4 and p53 are both central to cellular proliferation control, FOXO4-DRI serves as a valuable tool for understanding tumor-suppressor signaling, oncogene-induced senescence, and cellular checkpoints.
- Enables studies into how FOXO–p53 crosstalk contributes to cellular quiescence or programmed death in abnormal cells.
Molecular Pathway Mapping
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- Utilized in mechanistic studies examining transcriptional regulation, nuclear translocation, and protein–protein binding affinity.
- Offers researchers insight into selective senescence signaling distinct from general apoptosis pathways.
Peptide Engineering & Drug-Discovery Research
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- As a D-retro-inverso peptide, FOXO4-DRI demonstrates enhanced metabolic stability and resistance to enzymatic degradation, making it a model for studying therapeutic peptide design and cell-penetrating peptide analogs.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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