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FRAGMENT

FRAGMENT

HGH Fragment 176-191 is a synthetic peptide fragment derived from the human Growth Hormone (HGH) molecule, encompassing amino acid residues 176 through 191 at the C-terminal end of the 191-amino acid HGH polypeptide.

This short peptide sequence retains the primary lipolytic (fat-mobilizing) domain of the native growth hormone but lacks its insulin-antagonistic and proliferative effects, allowing researchers to isolate and study HGH’s metabolic and fat-regulatory properties without influencing growth factor pathways.

In laboratory research, Fragment 176-191 is utilized as a GH-derived lipolytic model peptide to investigate fat metabolism, energy expenditure, mitochondrial function, and obesity-related metabolic regulation.
Its selective mechanism of action makes it an ideal tool for studying the biochemical pathways of lipid oxidation and adipocyte signaling independent of full-length HGH activity.

Price range: $44.00 through $72.00

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HGH Fragment 176-191 is a synthetic peptide fragment derived from the human Growth Hormone (HGH) molecule, encompassing amino acid residues 176 through 191 at the C-terminal end of the 191-amino acid HGH polypeptide. This short peptide sequence retains the primary lipolytic (fat-mobilizing) domain of the native growth hormone but lacks its insulin-antagonistic and proliferative effects, allowing researchers to isolate and study HGH’s metabolic and fat-regulatory properties without influencing growth factor pathways. In laboratory research, Fragment 176-191 is utilized as a GH-derived lipolytic model peptide to investigate fat metabolism, energy expenditure, mitochondrial function, and obesity-related metabolic regulation. Its selective mechanism of action makes it an ideal tool for studying the biochemical pathways of lipid oxidation and adipocyte signaling independent of full-length HGH activity.
Property
Specification
Peptide Type:
Synthetic fragment of human Growth Hormone (HGH 176–191)
Sequence (1-Letter Code):
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Ser-Cys-Gly-Phe-OH
Length:
16 amino acids
Molecular Formula:
C₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight:
~1815.08 Da
Structure Type:
Linear peptide, C-terminal amidated variant (optional)
Charge State:
Slightly basic at physiological pH
Solubility:
Water and mild aqueous buffers
Storage Conditions:
–20 °C, dry and protected from light

Structural Highlights:

  • Derived from HGH’s C-terminal region (residues 176–191): The fragment represents the segment responsible for the hormone’s lipolytic activity, without somatogenic or diabetogenic effects.
  • Structure–Activity Relationship: Maintains binding affinity to adipocyte β-adrenergic and GH receptor-associated sites involved in lipid metabolism.
  • Non-Proliferative Design: Does not induce IGF-1 expression or interfere with glucose utilization — distinguishing it from native HGH.
  • Compact and Stable: Short, unmodified peptide structure provides excellent bioactivity in controlled in-vitro systems.

Mechanism of Action

Fragment 176-191 exerts its primary effects on adipose tissue metabolism. Research demonstrates that it enhances lipolysis (the breakdown of stored fat) and inhibits lipogenesis (the creation of new fat cells).

Mechanistically, it operates by:

  • Stimulating adenylate cyclase activity within adipocytes, increasing cyclic AMP (cAMP) levels.
  • Upregulating hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) enzymes.
  • Modulating β-adrenergic receptor pathways, similar to but more selective than native HGH.

Unlike full-length Growth Hormone, Fragment 176-191 does not raise insulin resistance, blood glucose levels, or IGF-1 expression, allowing targeted study of GH-dependent fat metabolism.

Lipolysis and Fat Metabolism Research

  • Promotes triglyceride breakdown and fatty-acid mobilization in adipocyte culture models.
  • Inhibits de-novo lipogenesis (fat cell formation) in preadipocyte differentiation assays.
  • Provides a reliable platform for studying obesity, lipid oxidation, and metabolic adaptation.

Energy Regulation and Mitochondrial Function

  • Increases cellular energy turnover through enhanced β-oxidation of fatty acids.
  • Supports studies on metabolic thermogenesis, energy homeostasis, and AMPK pathway activation.
  • Serves as a comparative control peptide in GH receptor and mitochondrial metabolism research.

Anabolic and Regenerative Biology

  • Enhances muscle preservation during caloric restriction models (via preferential fat utilization).
  • Investigated in conjunction with CJC-1295 and Ipamorelin in GH-axis synergy research.
  • Offers insight into GH fragment bioactivity independent of proliferative or glycemic effects.

Endocrine and Feedback Mechanism Studies

  • Enables isolation of HGH’s metabolic domains from its anabolic or mitogenic regions.
  • Facilitates exploration of GH receptor partial agonism, signal transduction, and metabolic cross-talk between GH and ghrelin systems.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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