5-AMINO-1MQ
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule methyltransferase inhibitor that has gained significant attention in metabolic and aging research for its potent ability to inhibit nicotinamide N-methyltransferase (NNMT) — a key enzyme involved in cellular energy regulation, NAD⁺ metabolism, and epigenetic control.
NNMT is overexpressed in various metabolic disorders and cancers, where it acts as a metabolic “sink,” depleting cellular nicotinamide and lowering NAD⁺ availability. By selectively blocking NNMT activity, 5-Amino-1MQ helps restore intracellular NAD⁺ levels, enhance sirtuin signaling, and rebalance metabolic homeostasis.
This compound has been studied extensively for its potential roles in adiposity reduction, metabolic enhancement, mitochondrial function, longevity pathways, and cellular energy regulation.
Price range: $55.00 through $70.00
Structural Highlights:
- Core Scaffold: Quinoline-based heterocyclic ring system with a methyl group at the N-1 position and an amino substitution at the 5-position.
- Cationic Charge: Exists as a quaternary ammonium cation, enhancing solubility and interaction with the NNMT enzyme active site.
- Mechanistic Target: Direct, competitive inhibition of NNMT, preventing methylation of nicotinamide and preserving cellular NAD⁺ pools.
5-Amino-1MQ is widely used in metabolic and biochemical research to explore the downstream effects of NNMT inhibition. Preclinical studies suggest a broad range of potential biological impacts, including metabolic, mitochondrial, and cellular energy regulation effects.
Metabolic Regulation & NAD⁺ Restoration
- Inhibits NNMT, a critical enzyme that consumes nicotinamide and lowers NAD⁺ levels.
- Increases intracellular NAD⁺ availability, supporting sirtuin activity (SIRT1, SIRT3) and enhancing metabolic function.
- Improves insulin sensitivity and glucose utilization in metabolic research models.
Adipose Tissue and Weight Research
- Shown in preclinical studies to reduce adipocyte size and limit fat accumulation by altering metabolic gene expression.
- Inhibits pathways that drive adipogenesis and enhances lipolytic activity in fat tissue.
- Associated with improved mitochondrial function and increased energy expenditure in experimental systems.
Cellular Energy & Longevity Pathways
- Promotes enhanced mitochondrial biogenesis and ATP production in cellular studies.
- Supports activation of key longevity-associated pathways (e.g., SIRT1, AMPK) via increased NAD⁺ availability.
- Investigated as a tool for studying cellular senescence, epigenetic regulation, and metabolic aging.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
5-AMINO-1MQ(251435)
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