CARGRILINTIDE
Cagrilintide (CARGRILINTIDE) is a synthetic, long-acting amylin analogue engineered for metabolic and appetite regulation research. It is derived from the human amylin (islet amyloid polypeptide, IAPP) sequence and optimized with amino acid substitutions and a C-terminal lipid modification that significantly extend its half-life and biological stability.
In pre-clinical and in-vitro research, Cagrilintide acts as a potent dual amylin and calcitonin receptor agonist (DACRA). This dual mechanism allows it to influence satiety signaling, energy expenditure, and body weight regulation independent of insulin or glucose transport mechanisms.
Due to its long-acting pharmacological profile and receptor selectivity, Cagrilintide is frequently studied in models of obesity, metabolic syndrome, energy balance, and peptide synergy research, especially when paired with GLP-1 receptor agonists such as semaglutide or tirzepatide.
$59.00
1. Appetite Regulation and Satiety Signaling Research
- Cagrilintide activates amylin and calcitonin receptors in the central nervous system involved in appetite suppression and food intake control.
- Demonstrated in studies to prolong satiety, reduce feeding frequency, and lower overall caloric intake.
- Provides a robust model for neuropeptide-based appetite signaling and metabolic control research.
2. Energy Balance and Weight Regulation Studies
- Promotes energy expenditure and thermogenesis through central hypothalamic pathways.
- Serves as a long-acting model for studying energy balance modulation and adaptive metabolic signaling.
- Often used in research alongside GLP-1 analogs to examine synergistic effects on body weight reduction and metabolic improvement.
3. Lipid and Glucose Metabolism Research
- Supports investigation into peptide-mediated lipid oxidation, fat mobilization, and insulin sensitivity regulation.
- Unlike GLP-1 receptor agonists, Cagrilintide does not directly stimulate insulin secretion, allowing differentiation of glucose-independent metabolic effects.
4. Dual Amylin–Calcitonin Receptor Mechanism Studies
- Unique DACRA (Dual Amylin and Calcitonin Receptor Agonist) activity allows exploration of CNS and peripheral receptor interactions.
- Enables researchers to study multi-receptor peptide dynamics in energy homeostasis and neuroendocrine regulation.
5. Combination Peptide Research (Synergistic Models)
- Extensively studied in combination with GLP-1 receptor agonists (e.g., semaglutide, tirzepatide) for enhanced weight loss and metabolic outcomes.
- Provides an ideal platform for exploring multi-hormonal peptide synergy and metabolic optimization pathways.
6. Pharmacokinetic and Peptide Stability Studies
- Its C18 lipid chain modification extends half-life by increasing albumin binding and reducing renal clearance.
- Used to analyze peptide delivery systems, stability profiles, and long-acting analog development in peptide pharmacology.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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