CJC-1295 (DAC)
CJC-1295 with DAC is a synthetic analog of Growth Hormone Releasing Hormone (GHRH-1-29) that has been chemically modified with a Drug Affinity Complex (DAC) to extend its half-life and enhance its stability in biological systems.
In scientific research, CJC-1295 is used to study growth hormone (GH) secretion dynamics, pituitary receptor activation, and endocrine feedback regulation. The DAC modification allows the peptide to bind to serum albumin, significantly extending its duration of action compared to native GHRH or short-acting analogs such as CJC-1295 without DAC or Modified GRF (1-29).
CJC-1295 with DAC has been explored in pre-clinical and in-vitro research related to GH pulsatility, IGF-1 synthesis, tissue growth signaling, and metabolic homeostasis, offering a model system for understanding how controlled GH release affects multiple physiological pathways.
$43.00
The following research areas reflect pre-clinical and in-vitro studies only. CJC-1295 with DAC is not approved for human use and is supplied strictly for laboratory research
1. Growth Hormone Release and Pituitary Function Studies
- Investigated for its ability to stimulate pulsatile GH secretion through activation of GHRH receptors on somatotroph cells.
- The DAC modification allows researchers to study sustained GH elevation over extended time frames compared to unmodified GHRH analogs.
- Used to evaluate pituitary receptor sensitivity, feedback regulation, and GH/IGF-1 axis interactions.
2. Extended-Action Pharmacokinetics Research
- The Drug Affinity Complex (DAC) forms a stable covalent bond with serum albumin, dramatically prolonging the peptide’s half-life from ~30 minutes to several days.
- Enables long-duration kinetic modeling of GH release and albumin-binding pharmacodynamics in research environments.
3. IGF-1 and Growth Pathway Mechanisms
- Studied for its indirect stimulation of Insulin-like Growth Factor-1 (IGF-1) production in hepatic cells.
- Provides a model for examining somatotropic signaling, cellular growth, and protein synthesis pathways in GH-regulated tissues.
4. Metabolic and Energy Homeostasis Research
- Explored in studies focusing on lipid metabolism, glucose utilization, and energy regulation under GH-modulated conditions.
- Helps elucidate how GH pulse amplitude and frequency affect metabolic balance in pre-clinical models.
5. Cellular Regeneration and Recovery Pathways
- Enables investigation of GH-mediated cellular proliferation, repair, and differentiation in muscle and connective tissue cell cultures.
- Supports research into GH receptor cross-talk with other anabolic and regenerative signaling cascades.
6. Comparative Endocrine Studies
- Provides researchers with a tool to compare short-acting GHRH analogs (e.g., CJC-1295 without DAC, Modified GRF 1-29) to long-acting formulations, allowing in-depth analysis of peptide stability and receptor occupancy over time.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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