CJC-1295 + IPAMORELIN
CJC-1295 + Ipamorelinis a synergistic dual-peptide research formulation that combines two distinct growth hormone secretagogues acting through complementary mechanisms to enhance growth hormone (GH) pulsatility, pituitary stimulation, and somatotropic axis activity.
- CJC-1295 is a synthetic GHRH (Growth Hormone–Releasing Hormone) analogue modified with a Drug Affinity Complex (DAC) to extend plasma half-life and prolong GH release.
- Ipamorelin is a selective ghrelin receptor agonist (GHSR-1a) and pentapeptide growth hormone secretagogue that triggers GH secretion without elevating cortisol or prolactin levels.
Together, they model multi-pathway stimulation of the GH axis, making this combination an invaluable tool in endocrine, metabolic, and regenerative peptide research.
$60.00
- CJC-1295 is a synthetic GHRH (Growth Hormone–Releasing Hormone) analogue modified with a Drug Affinity Complex (DAC) to extend plasma half-life and prolong GH release.
- Ipamorelin is a selective ghrelin receptor agonist (GHSR-1a) and pentapeptide growth hormone secretagogue that triggers GH secretion without elevating cortisol or prolactin levels.
Mechanism of Action
CJC-1295 (GHRH Analogue):
Stimulates the pituitary gland’s GHRH receptors, enhancing endogenous GH pulse frequency and amplitude. The DAC modification allows sustained binding to albumin, extending activity and providing continuous GH elevation for up to a week in preclinical models.
Ipamorelin (Ghrelin Mimetic):
Binds to the GHSR-1a receptor, promoting GH release through a ghrelin-like pathway independent of GHRH. Ipamorelin selectively induces GH secretion without increasing ACTH, prolactin, or cortisol, offering a clean research profile for pure GH-axis stimulation.
When combined, these peptides act synergistically — CJC-1295 drives steady, long-term GH signaling, while Ipamorelin induces rapid, pulsatile spikes — creating a comprehensive model for naturalistic GH regulation and pituitary responsiveness.
Scientific Significance
This dual-pathway combination is used extensively in studies of:
- Growth hormone deficiency models
- Somatotropic axis regulation and circadian rhythm effects
- Metabolic and body composition pathways (fat oxidation, protein synthesis)
- Cellular regeneration and mitochondrial function
- Age-related endocrine decline and feedback inhibition mechanisms
Growth Hormone Secretion Dynamics
- Enhances both GH pulse frequency (via GHRH receptor stimulation) and amplitude (via GHSR-1a activation).
- Increases total circulating IGF-1 levels in preclinical endocrine models.
- Provides a model for investigating dual receptor synergy in GH modulation.
Metabolic and Lipid Regulation
- Stimulates lipolysis and fatty acid oxidation in adipose tissue cultures.
- Promotes protein synthesis and muscle-cell differentiation in vitro.
- Supports studies on energy balance, metabolic efficiency, and insulin sensitivity.
Cellular Regeneration and Repair
- GH/IGF-1 signaling pathways are linked to collagen synthesis, tissue regeneration, and wound healing.
- Used in research exploring neuroendocrine repair, mitochondrial biogenesis, and GH-related anti-aging effects.
Endocrine and Feedback Loop Research
- Allows study of hypothalamic-pituitary feedback inhibition and somatostatin modulation.
- Serves as a comparative model for long-acting vs. pulsatile secretagogue activity.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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