Facebook Instagram
CJC-1295 + IPAMORELIN
CJC-1295 + IPAMORELIN - Image 2

CJC-1295 + IPAMORELIN

CJC-1295 + Ipamorelinis a synergistic dual-peptide research formulation that combines two distinct growth hormone secretagogues acting through complementary mechanisms to enhance growth hormone (GH) pulsatility, pituitary stimulation, and somatotropic axis activity.

  • CJC-1295 is a synthetic GHRH (Growth Hormone–Releasing Hormone) analogue modified with a Drug Affinity Complex (DAC) to extend plasma half-life and prolong GH release.
  • Ipamorelin is a selective ghrelin receptor agonist (GHSR-1a) and pentapeptide growth hormone secretagogue that triggers GH secretion without elevating cortisol or prolactin levels.

Together, they model multi-pathway stimulation of the GH axis, making this combination an invaluable tool in endocrine, metabolic, and regenerative peptide research.

$60.00

$60.00
1 - 2
$48.00 (20% off)
3 - 5
$42.00 (30% off)
6 - 9
$36.00 (40% off)
10+
Category
CJC-1295 + Ipamorelinis a synergistic dual-peptide research formulation that combines two distinct growth hormone secretagogues acting through complementary mechanisms to enhance growth hormone (GH) pulsatility, pituitary stimulation, and somatotropic axis activity.
  • CJC-1295 is a synthetic GHRH (Growth Hormone–Releasing Hormone) analogue modified with a Drug Affinity Complex (DAC) to extend plasma half-life and prolong GH release.
  • Ipamorelin is a selective ghrelin receptor agonist (GHSR-1a) and pentapeptide growth hormone secretagogue that triggers GH secretion without elevating cortisol or prolactin levels.
Together, they model multi-pathway stimulation of the GH axis, making this combination an invaluable tool in endocrine, metabolic, and regenerative peptide research.
Property
CJC-1295
Ipamorelin
Peptide Type:
GHRH analogue (with DAC modification)
Synthetic pentapeptide, ghrelin mimetic
Sequence (1-Letter Code):
Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Kys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Gln-Gly-Ala-Arg-Ala-Arg-Leu-NH₂ (with DAC linker)
Aib-HomoArg-Aib-D-2-Nal-D-Phe-NH₂
Length:
30–44 amino acids (depending on variant)
5 amino acids
Molecular Formula:
~C₁₅₂H₂₅₂N₄₄O₄₂S (approximate)
C₃₈H₄₉N₉O₅
Molecular Weight:
~3647–5000 Da (variant dependent)
~711.9 Da
Structure Type:
Linear peptide (amide form)
Linear pentapeptide (C-terminal amidated)
Mechanistic Target:
GHRH receptor on pituitary somatotrophs
Ghrelin/GHSR-1a receptor in pituitary and hypothalamus
Modifications:
DAC conjugation (maleimide linker to albumin) for prolonged half-life
D-amino acid substitutions for selectivity and stability
Solubility:
Water, PBS
Water, PBS
Half-Life (Preclinical):
~6–8 days
~2 hours (acute release)

Mechanism of Action

CJC-1295 (GHRH Analogue):
Stimulates the pituitary gland’s GHRH receptors, enhancing endogenous GH pulse frequency and amplitude. The DAC modification allows sustained binding to albumin, extending activity and providing continuous GH elevation for up to a week in preclinical models.

Ipamorelin (Ghrelin Mimetic):
Binds to the GHSR-1a receptor, promoting GH release through a ghrelin-like pathway independent of GHRH. Ipamorelin selectively induces GH secretion without increasing ACTH, prolactin, or cortisol, offering a clean research profile for pure GH-axis stimulation.

When combined, these peptides act synergistically — CJC-1295 drives steady, long-term GH signaling, while Ipamorelin induces rapid, pulsatile spikes — creating a comprehensive model for naturalistic GH regulation and pituitary responsiveness.

Scientific Significance

This dual-pathway combination is used extensively in studies of:

  • Growth hormone deficiency models
  • Somatotropic axis regulation and circadian rhythm effects
  • Metabolic and body composition pathways (fat oxidation, protein synthesis)
  • Cellular regeneration and mitochondrial function
  • Age-related endocrine decline and feedback inhibition mechanisms

Growth Hormone Secretion Dynamics

  • Enhances both GH pulse frequency (via GHRH receptor stimulation) and amplitude (via GHSR-1a activation).
  • Increases total circulating IGF-1 levels in preclinical endocrine models.
  • Provides a model for investigating dual receptor synergy in GH modulation.

Metabolic and Lipid Regulation

  • Stimulates lipolysis and fatty acid oxidation in adipose tissue cultures.
  • Promotes protein synthesis and muscle-cell differentiation in vitro.
  • Supports studies on energy balance, metabolic efficiency, and insulin sensitivity.

Cellular Regeneration and Repair

  • GH/IGF-1 signaling pathways are linked to collagen synthesis, tissue regeneration, and wound healing.
  • Used in research exploring neuroendocrine repair, mitochondrial biogenesis, and GH-related anti-aging effects.

Endocrine and Feedback Loop Research

  • Allows study of hypothalamic-pituitary feedback inhibition and somatostatin modulation.
  • Serves as a comparative model for long-acting vs. pulsatile secretagogue activity.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

BAC WATER

Price range: $6.00 through $9.99
Add to Cart

SELANK

$25.00
Add to Cart

Melanotan 2

$34.00
Add to Cart

PT 141

$34.00
Add to Cart

Related Product

Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

What are you looking for today?