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FOXO4-DRI

FOXO4-DRI

FOXO4-DRI (also known as FOXO4-D-Retro-Inverso peptide) is a synthetic, D-amino acid peptide derived from the FOXO4 transcription factor—a member of the forkhead box O (FOXO) protein family involved in cell cycle regulation, stress response, and cellular aging.

In scientific research, FOXO4-DRI is studied for its ability to modulate interactions between FOXO4 and the tumor suppressor protein p53, a key regulator of cellular senescence and apoptosis. Through this pathway, FOXO4-DRI provides researchers with a tool for investigating cellular aging, DNA damage response, and senescence-associated secretory phenotype (SASP) mechanisms in vitro and in pre-clinical models.

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FOXO4-DRI (also known as FOXO4-D-Retro-Inverso peptide) is a synthetic, D-amino acid peptide derived from the FOXO4 transcription factor—a member of the forkhead box O (FOXO) protein family involved in cell cycle regulation, stress response, and cellular aging. In scientific research, FOXO4-DRI is studied for its ability to modulate interactions between FOXO4 and the tumor suppressor protein p53, a key regulator of cellular senescence and apoptosis. Through this pathway, FOXO4-DRI provides researchers with a tool for investigating cellular aging, DNA damage response, and senescence-associated secretory phenotype (SASP) mechanisms in vitro and in pre-clinical models.
Property
Specification
Peptide Name:
FOXO4-DRI (D-Retro-Inverso Peptide)
Sequence (Retro-Inverso):
D-Arg-D-Tyr-D-Lys-D-Asp-D-Leu-D-Tyr-D-Gln-D-Asn-D-Ser-D-Phe-D-Cys-D-Thr-D-Glu-D-Lys-D-Ser-D-Tyr-D-Cys-D-Glu-D-Thr-D-Ser-D-Asp-D-Tyr-D-Leu-D-Arg-amide
Molecular Formula:
Variable; depends on protecting groups (approx. C₁₄₀H₂₁₀N₄₆O₄₆S₂)
Molecular Weight:
~3900 Da
Peptide Type:
D-retro-inverso (sequence inverted and composed of D-amino acids for enhanced stability)
Form:
Lyophilized white powder
Purity:
99 % (HPLC verified)
Solubility:
Soluble in sterile water or 0.1 % acetic acid for laboratory reconstitution
Storage:
–20 °C in a dry, dark environment
Stability:
Stable for 24 months when stored properly

 

The following points describe potential research applications derived from pre-clinical literature.

FOXO4-DRI is not intended for human use and not approved by the FDA.

Cellular Senescence Studies

    • FOXO4-DRI has been used to study mechanisms that govern senescent cell survival by interfering with the FOXO4-p53 protein interaction, which may influence how cells respond to DNA damage or oxidative stress in vitro.
    • Enables researchers to explore senolytic pathways and selective apoptosis of senescent cells in controlled models.

Aging and Longevity Mechanisms

    • Provides a platform to investigate the molecular biology of cellular aging, mitochondrial dysfunction, and genomic stability.
    • Helps identify signaling cascades linking FOXO transcription factors with age-associated cell cycle arrest.

DNA Damage and Stress Response Research

    • Used to assess p53 activation, nuclear localization, and transcriptional activity in response to genotoxic stress.
    • Supports research into cellular repair mechanisms, oxidative stress modulation, and apoptotic regulation.

Cancer Biology Investigations

    • Because FOXO4 and p53 are both central to cellular proliferation control, FOXO4-DRI serves as a valuable tool for understanding tumor-suppressor signaling, oncogene-induced senescence, and cellular checkpoints.
    • Enables studies into how FOXO–p53 crosstalk contributes to cellular quiescence or programmed death in abnormal cells.

Molecular Pathway Mapping

    • Utilized in mechanistic studies examining transcriptional regulation, nuclear translocation, and protein–protein binding affinity.
    • Offers researchers insight into selective senescence signaling distinct from general apoptosis pathways.

Peptide Engineering & Drug-Discovery Research

    • As a D-retro-inverso peptide, FOXO4-DRI demonstrates enhanced metabolic stability and resistance to enzymatic degradation, making it a model for studying therapeutic peptide design and cell-penetrating peptide analogs.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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