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GHRP-2

GHRP-2

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the ghrelin mimetic and Growth Hormone Secretagogue (GHS) family. It acts primarily on the ghrelin/GHS-R1a receptor in the hypothalamus and pituitary gland, stimulating the natural release of growth hormone (GH) through a mechanism independent of the Growth Hormone Releasing Hormone (GHRH) pathway.

In pre-clinical research, GHRP-2 is used to study endocrine regulation, growth hormone pulsatility, appetite signaling, and cellular metabolism. It has shown strong affinity for both the pituitary somatotrophs and hypothalamic neurons, making it valuable for understanding GH axis modulation, IGF-1 feedback loops, and metabolic response pathways.

Price range: $19.00 through $63.00

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1 - 2
$15.20 (20% off)
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$13.30 (30% off)
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$11.40 (40% off)
10+
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GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the ghrelin mimetic and Growth Hormone Secretagogue (GHS) family. It acts primarily on the ghrelin/GHS-R1a receptor in the hypothalamus and pituitary gland, stimulating the natural release of growth hormone (GH) through a mechanism independent of the Growth Hormone Releasing Hormone (GHRH) pathway. In pre-clinical research, GHRP-2 is used to study endocrine regulation, growth hormone pulsatility, appetite signaling, and cellular metabolism. It has shown strong affinity for both the pituitary somatotrophs and hypothalamic neurons, making it valuable for understanding GH axis modulation, IGF-1 feedback loops, and metabolic response pathways.
Property
Specification
Peptide Name:
Growth Hormone Releasing Peptide-2 (GHRP-2)
Sequence:
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
Amino Acid Length:
6
Molecular Formula:
C45H55N9O6
Molecular Weight:
~817.0 Da
CAS Number:
158861-67-7
Peptide Type:
Synthetic Growth Hormone Secretagogue (GHS)
Structure Type:
Hexapeptide amide
Form:
Lyophilized white to off-white powder
Purity:
99 % (HPLC verified)
Solubility:
Soluble in sterile water, PBS, or 0.1 % acetic acid for research reconstitution
Storage:
−20 °C, protected from light and moisture
Stability:
Stable for 24 months under recommended storage conditions

Growth Hormone Secretion and Pituitary Function

  • GHRP-2 binds to the ghrelin receptor (GHS-R1a), activating intracellular Ca²⁺ and PKC signaling, leading to robust GH pulse release in pre-clinical models.
  • Used to investigate growth hormone secretory profiles, feedback regulation, and synergistic interaction with GHRH analogs (such as CJC-1295).
  • Provides a precise model for studying somatotropic axis dynamics and GH pulse frequency modulation.

IGF-1 and Anabolic Signaling Research

  • Indirectly increases hepatic IGF-1 expression, which mediates cellular growth, differentiation, and protein synthesis.
  • Enables research on IGF-1/PI3K/mTOR pathway activation, muscle regeneration, and metabolic tissue remodeling.

Appetite Regulation and Ghrelin Pathway Studies

  • GHRP-2 interacts with hypothalamic ghrelin receptors, making it a key compound for studying orexigenic (appetite-stimulating) mechanisms and energy intake regulation.
  • Commonly used to explore neuropeptide Y (NPY) and Agouti-related peptide (AgRP) signaling in the hypothalamus.

Endocrine Axis and Hormonal Balance Models

  • Provides a reproducible model for analyzing pituitary–hypothalamic cross-communication and GH–IGF-1 axis feedback.
  • Used to evaluate peptide-based endocrine modulation in research involving metabolic, reproductive, and stress-response hormones.

Cellular Metabolism and Mitochondrial Studies

  • GHRP-2 has been utilized to investigate mitochondrial biogenesis, lipid oxidation, and insulin sensitivity through GH-dependent pathways.
  • Offers data for metabolic rate modulation, glucose uptake regulation, and energy expenditure research.

Tissue Repair and Regenerative Research

  • Via GH and IGF-1 up-regulation, GHRP-2 contributes to research exploring tissue recovery, collagen synthesis, and fibroblast proliferation.
  • Often paired with BPC-157 or TB-500 in studies on soft-tissue regeneration and healing mechanisms.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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