GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the ghrelin mimetic and Growth Hormone Secretagogue (GHS) family. It acts primarily on the ghrelin/GHS-R1a receptor in the hypothalamus and pituitary gland, stimulating the natural release of growth hormone (GH) through a mechanism independent of the Growth Hormone Releasing Hormone (GHRH) pathway.
In pre-clinical research, GHRP-2 is used to study endocrine regulation, growth hormone pulsatility, appetite signaling, and cellular metabolism. It has shown strong affinity for both the pituitary somatotrophs and hypothalamic neurons, making it valuable for understanding GH axis modulation, IGF-1 feedback loops, and metabolic response pathways.
Price range: $19.00 through $63.00
Growth Hormone Secretion and Pituitary Function
- GHRP-2 binds to the ghrelin receptor (GHS-R1a), activating intracellular Ca²⁺ and PKC signaling, leading to robust GH pulse release in pre-clinical models.
- Used to investigate growth hormone secretory profiles, feedback regulation, and synergistic interaction with GHRH analogs (such as CJC-1295).
- Provides a precise model for studying somatotropic axis dynamics and GH pulse frequency modulation.
IGF-1 and Anabolic Signaling Research
- Indirectly increases hepatic IGF-1 expression, which mediates cellular growth, differentiation, and protein synthesis.
- Enables research on IGF-1/PI3K/mTOR pathway activation, muscle regeneration, and metabolic tissue remodeling.
Appetite Regulation and Ghrelin Pathway Studies
- GHRP-2 interacts with hypothalamic ghrelin receptors, making it a key compound for studying orexigenic (appetite-stimulating) mechanisms and energy intake regulation.
- Commonly used to explore neuropeptide Y (NPY) and Agouti-related peptide (AgRP) signaling in the hypothalamus.
Endocrine Axis and Hormonal Balance Models
- Provides a reproducible model for analyzing pituitary–hypothalamic cross-communication and GH–IGF-1 axis feedback.
- Used to evaluate peptide-based endocrine modulation in research involving metabolic, reproductive, and stress-response hormones.
Cellular Metabolism and Mitochondrial Studies
- GHRP-2 has been utilized to investigate mitochondrial biogenesis, lipid oxidation, and insulin sensitivity through GH-dependent pathways.
- Offers data for metabolic rate modulation, glucose uptake regulation, and energy expenditure research.
Tissue Repair and Regenerative Research
- Via GH and IGF-1 up-regulation, GHRP-2 contributes to research exploring tissue recovery, collagen synthesis, and fibroblast proliferation.
- Often paired with BPC-157 or TB-500 in studies on soft-tissue regeneration and healing mechanisms.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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