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KISSPEPTIN

KISSPEPTIN

Kisspeptin (also known as metastin) is a naturally occurring neuropeptide encoded by the KISS1 gene and acts as a critical regulator of the hypothalamic–pituitary–gonadal (HPG) axis.
This peptide family (including Kisspeptin-10, 13, 14, and 54 variants) binds with high affinity to the G-protein–coupled receptor GPR54 (KISS1R) to stimulate Gonadotropin-Releasing Hormone (GnRH) secretion.

In pre-clinical and in-vitro models, Kisspeptin has been studied for its role in pubertal development, reproductive signaling, and neuroendocrine feedback regulation.
Because of its precision in activating the HPG axis without broadly altering other hormones, Kisspeptin serves as an essential tool for studying fertility regulation, hormonal synchronization, and neuropeptide signaling cascades.

Price range: $45.00 through $59.00

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Kisspeptin (also known as metastin) is a naturally occurring neuropeptide encoded by the KISS1 gene and acts as a critical regulator of the hypothalamic–pituitary–gonadal (HPG) axis. This peptide family (including Kisspeptin-10, 13, 14, and 54 variants) binds with high affinity to the G-protein–coupled receptor GPR54 (KISS1R) to stimulate Gonadotropin-Releasing Hormone (GnRH) secretion. In pre-clinical and in-vitro models, Kisspeptin has been studied for its role in pubertal development, reproductive signaling, and neuroendocrine feedback regulation. Because of its precision in activating the HPG axis without broadly altering other hormones, Kisspeptin serves as an essential tool for studying fertility regulation, hormonal synchronization, and neuropeptide signaling cascades.
Property
Specification
Peptide Name:
Ipamorelin
Sequence:
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Amino Acid Length:
5
Molecular Formula:
C38H49N9O5
Molecular Weight:
~711.86 Da
CAS Number:
170851-70-4
Peptide Type:
Synthetic Growth Hormone Secretagogue (Ghrelin mimetic)
Structure Type:
Linear pentapeptide amide
Form:
Lyophilized white/off-white powder
Purity:
99 % (HPLC verified)
Solubility:
Soluble in sterile water, PBS, or 0.1 % acetic acid for reconstitution
Storage:
−20 °C, protected from light and moisture
Stability:
Stable for 24 months under recommended storage conditions

Reproductive and Gonadotropin Regulation Research

  • Acts directly on hypothalamic GnRH neurons, inducing pulsatile GnRH release and downstream LH/FSH stimulation.
  • Enables study of neuroendocrine feedback loops governing fertility, puberty onset, and ovulatory cycles.
  • Serves as a model for mapping GPR54/KISS1R signaling pathways in reproductive endocrinology.

Puberty and Developmental Signaling Studies

  • Used to explore pubertal initiation mechanisms, including how kisspeptin–GnRH coupling coordinates sexual maturation.
  • Provides data on estrogen and testosterone feedback modulation through kisspeptin-neuronal pathways.

Hypothalamic–Pituitary–Gonadal (HPG) Axis Models

  • Supports investigation into GnRH pulse frequency control, pituitary gonadotropin synthesis, and hormonal homeostasis.
  • Commonly utilized in combination with GHRH or GnRH analogs to compare peptide-driven axis activation patterns.

Fertility and Reproductive Health Research

  • Enables analysis of peptide-based mechanisms regulating follicular development, spermatogenesis, and oocyte maturation.
  • Provides insight into neuropeptide interplay affecting fertility restoration and cycle synchronization in pre-clinical models.

Metabolic and Energy Balance Studies

  • Kisspeptin signaling has been linked to energy availability and reproductive function, making it a useful model for studying metabolic endocrinology.
  • Allows research on how nutrient status and leptin affect GnRH neuronal sensitivity via kisspeptin pathways.

Neuroendocrine and Behavioral Pathway Research

  • Explored in studies of sexual behavior, neuropeptide expression, and stress hormone interactions within the limbic system.
  • Provides insight into peptide-regulated neurotransmission and hormonal adaptation under stress.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

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