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KPV

KPV

KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal region of α-Melanocyte-Stimulating Hormone (α-MSH) — a naturally occurring neuropeptide involved in immune regulation, anti-inflammatory signaling, and tissue repair.

In pre-clinical and in-vitro research, KPV has been shown to exhibit potent anti-inflammatory, immunomodulatory, and epithelial barrier–protective properties. Its biological effects are primarily mediated through melanocortin-1 receptor (MC1R) and NF-κB signaling modulation, reducing the expression of pro-inflammatory cytokines and promoting cellular homeostasis.

KPV’s simplicity, stability, and short-chain structure make it a valuable compound for dermatological, gastrointestinal, and immunological research — especially in models exploring inflammation suppression, oxidative stress, and mucosal integrity.

$52.00

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KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal region of α-Melanocyte-Stimulating Hormone (α-MSH) — a naturally occurring neuropeptide involved in immune regulation, anti-inflammatory signaling, and tissue repair. In pre-clinical and in-vitro research, KPV has been shown to exhibit potent anti-inflammatory, immunomodulatory, and epithelial barrier–protective properties. Its biological effects are primarily mediated through melanocortin-1 receptor (MC1R) and NF-κB signaling modulation, reducing the expression of pro-inflammatory cytokines and promoting cellular homeostasis. KPV’s simplicity, stability, and short-chain structure make it a valuable compound for dermatological, gastrointestinal, and immunological research — especially in models exploring inflammation suppression, oxidative stress, and mucosal integrity.
Property
Specification
Peptide Name:
KPV (Lysine–Proline–Valine)
Sequence:
Lys–Pro–Val
Amino Acid Length:
3
Molecular Formula:
C17H32N4O4
Molecular Weight:
~356.46 Da
CAS Number:
80498-15-3
Peptide Type:
α-MSH tripeptide fragment
Structure Type:
Linear tripeptide
Form:
Lyophilized white crystalline powder
Purity:
99 % (HPLC verified)
Solubility:
Soluble in sterile water, ethanol, or PBS for laboratory use
Storage:
−20 °C, protected from light and moisture
Stability:
Stable for up to 24 months under recommended conditions

Anti-Inflammatory and Cytokine Modulation Research

  • KPV is studied for its ability to suppress pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, while enhancing anti-inflammatory IL-10 expression.
  • Regulates the NF-κB and JAK/STAT signaling pathways, key mediators in cellular inflammation.
  • Provides a model for examining peptide-based inflammatory control and immune regulation mechanisms.

Epithelial Barrier and Skin Integrity Studies

  • Used to explore keratinocyte migration, wound closure, and epithelial regeneration.
  • Promotes the study of skin barrier function, tight-junction integrity, and melanocortin signaling in epithelial systems.
  • Frequently applied in research on psoriasis, dermatitis, and UV-induced oxidative damage models.

Gastrointestinal and Mucosal Healing Research

  • Investigated for its protective effects on gut epithelium and mucosal barrier repair.
  • Enables research into colitis, IBD, and peptide-mediated intestinal homeostasis.
  • Supports the study of oxidative stress modulation and microbiome-associated inflammation.

Immune System Modulation Studies

  • Provides a research model for immune tolerance regulation, macrophage polarization, and autoimmune signaling balance.
  • Facilitates studies into MC1R receptor signaling and melanocortin immune pathways relevant to inflammatory and autoimmune mechanisms.

Wound Healing and Cellular Regeneration Research

  • Demonstrated in vitro to support fibroblast proliferation, collagen production, and re-epithelialization.
  • Used in pre-clinical models examining peptide-driven tissue regeneration and matrix remodeling under inflammatory stress.

Neuroendocrine and Stress Pathway Studies

  • KPV provides a framework for studying melanocortin peptides in neuroimmune regulation and stress-response mechanisms.
  • Useful for analyzing cross-talk between immune and neuroendocrine signaling in systemic inflammation research.

This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.

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Disclaimer: For Research Use Only

All products and information presented on this website are intended solely for laboratory and scientific research purposes. Nothing contained herein should be interpreted as a recommendation, endorsement, or authorization for human consumption, medical use, or diagnostic application.

Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.

All compounds are designed for controlled research environments and may be handled only by qualified professionals familiar with appropriate laboratory procedures and regulations. Customers and researchers are urged to consult with scientific, medical, or legal experts before ordering or utilizing any materials.

Revacta Labs promotes the ethical, safe, and lawful study of research-grade materials and expects all users to adhere to applicable local and federal guidelines. This disclaimer applies to all website content, communications, and products offered by Revacta Labs and is subject to change without notice.

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