MGF
MGF (Mechano Growth Factor), also known as IGF-1Ec, is a splice variant of the Insulin-Like Growth Factor-1 (IGF-1) gene that is expressed in response to mechanical overload, tissue damage, or cellular stress. This peptide sequence differs from standard IGF-1 by an altered E-domain, giving it distinct biological properties and a localized, short-term role in cellular growth and repair.
In pre-clinical and in-vitro research, MGF has been studied for its ability to activate satellite cells, stimulate muscle regeneration, and enhance tissue repair independent of systemic IGF-1 signaling. It is particularly valuable in models of skeletal muscle hypertrophy, cardiac repair, and cellular adaptation to mechanical stress.
$50.00
Muscle Regeneration and Satellite Cell Activation
- MGF is a critical component in studies of muscle fiber regeneration and myoblast proliferation.
- Shown in pre-clinical models to activate satellite cells—the resident stem cells responsible for muscle repair and hypertrophy.
- Provides a key model for understanding mechanotransduction, the cellular response to physical stress or injury.
Localized Anabolic Signaling
- Functions primarily in autocrine and paracrine pathways, producing localized anabolic effects distinct from systemic IGF-1 signaling.
- Used to study tissue-specific growth factor expression and short-acting peptide cascades following mechanical stress.
- Enables researchers to compare IGF-1Ec (MGF) with IGF-1 LR3 and IGF-1 DES (1–3) for differential growth responses.
Protein Synthesis and Cellular Growth Studies
- Stimulates mRNA translation, ribosomal biogenesis, and protein synthesis via PI3K/Akt and mTOR pathways.
- Provides a framework for analyzing peptide-induced anabolic signaling and muscle hypertrophy mechanisms in cell culture and animal models.
Injury Recovery and Tissue Repair Research
- Studied for its influence on fibroblast proliferation, collagen synthesis, and angiogenesis following tissue injury.
- Enables investigation into local peptide-mediated healing processes independent of systemic hormones.
- Often paired with BPC-157 and TB-500 in regenerative peptide research.
Cardiovascular and Ischemic Research
- MGF has demonstrated potential cardioprotective effects in pre-clinical studies by stimulating cardiac progenitor cell proliferation.
- Provides a model for myocardial repair and angiogenic recovery following ischemic events.
- Useful in research on cardiac peptide expression post-stress or injury.
Cellular Aging and Longevity Studies
- Investigated for its role in cellular turnover and mitochondrial protection within senescent muscle tissue.
- Offers a model for studying growth factor imbalance during aging and muscle atrophy prevention pathways.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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