MOTS-c
MOTS-C (Mitochondrial ORF of the Twelve S rRNA Type-C) is a 16-amino-acid mitochondrial-derived peptide (MDP) that plays a significant role in regulating cellular metabolism, insulin sensitivity, energy homeostasis, and stress responses. Unlike most peptides encoded in nuclear DNA, MOTS-C is encoded within the mitochondrial genome (mtDNA) — specifically within the 12S ribosomal RNA region — highlighting the critical role mitochondria play beyond energy production in metabolic signaling and cellular regulation.
MOTS-C acts as a metabolic modulator by influencing nuclear gene expression involved in glucose metabolism, AMPK activation, oxidative stress resistance, and mitochondrial function. It is widely used as a research tool to study aging, obesity, metabolic disorders, exercise physiology, and mitochondrial signaling pathways.
Price range: $47.00 through $98.00
Structural Highlights:
- Mitochondrial Origin: Encoded within mitochondrial DNA (12S rRNA region), distinguishing MOTS-C from nuclear-encoded peptides.
- Signaling Modulator: Functions as a retrograde signal — mitochondria → nucleus — altering gene expression related to metabolism and stress adaptation.
- AMPK Activation: Induces AMP-activated protein kinase (AMPK) pathways, promoting glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
- Adaptive Response: Plays a role in exercise-induced metabolic adaptation and cellular resilience under nutrient stress conditions.
MOTS-C has become a focus of intense scientific interest due to its wide range of metabolic and cellular effects observed in preclinical research. It is increasingly used to explore mechanisms of aging, metabolic disease, insulin resistance, exercise adaptation, and cellular stress tolerance.While MOTS-c is nota therapy, its ability to influence mitochondrial metabolism, AMPK signaling, cellular stress responses, and immune interactions makes it a promising subject in ongoing oncology research. Its unique mitochondrial origin gives scientists a powerful tool to study how metabolic regulation may shape cancer development, progression, and potential vulnerabilities.
Metabolic Regulation & Glucose Homeostasis
- Promotes AMPK activation, a central regulator of energy metabolism.
- Enhances glucose uptake and utilization in skeletal muscle and other tissues.
- Reduces insulin resistance and improves glucose tolerance in metabolic research models.
Mitochondrial Function & Energy Balance
- Enhances mitochondrial biogenesis and respiratory capacity.
- Modulates nuclear gene expression linked to energy homeostasis and oxidative metabolism.
- Improves cellular ATP production and metabolic efficiency under stress conditions.
Anti-Aging & Longevity Research
- Linked to improved cellular stress resilience and oxidative stress resistance in aging models.
- Modulates pathways associated with longevity and metabolic health, including AMPK and SIRT signaling.
- Investigated for its role in age-related metabolic decline, mitochondrial dysfunction, and metabolic inflammation.
Exercise Physiology & Adaptation
- Mimics exercise-induced molecular changes, including increased glucose utilization and fatty acid oxidation.
- Enhances exercise performance and endurance in animal models.
- Supports research into metabolic flexibility and skeletal muscle adaptation.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Disclaimer: For Research Use Only
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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