VIP
VIP (Vasoactive Intestinal Peptide) is a 28–amino acid neuropeptide that belongs to the secretin/glucagon peptide family. It was first identified in the intestinal tract but is now known to be widely distributed throughout the central and peripheral nervous systems, where it functions as a neurotransmitter, neuromodulator, and vasodilatory signaling peptide.
In scientific research, VIP is used to study smooth-muscle relaxation, vasodilation, immune modulation, and neuroprotective signaling. It plays a critical role in regulating cyclic adenosine monophosphate (cAMP) production, ion transport, and circadian rhythm control, making it an essential target for investigating neuroendocrine, cardiovascular, and immune regulatory pathways.
$100.00
Neurotransmission and Neuroprotection
- Studied for its ability to modulate neuronal excitability and protect neurons from oxidative or excitotoxic stress.
- Provides a model system to examine neurotrophic signaling, synaptic plasticity, and central nervous system repair mechanisms.
- Enables investigation into peptide-based neuroimmune communication and the regulation of glial cell activation.
Vascular and Smooth-Muscle Regulation
- Known for its potent vasodilatory effects; VIP stimulates cAMP-mediated smooth-muscle relaxation in vascular, respiratory, and gastrointestinal tissues.
- Used in studies examining blood-flow regulation, pulmonary function, and nitric-oxide–independent vasodilation mechanisms.
- Assists in mapping receptor subtypes VPAC1 and VPAC2, which are key targets for vascular homeostasis research.
Immune Modulation and Cytokine Regulation
- Explored in pre-clinical settings for its role in modulating cytokine synthesis, particularly in the suppression of pro-inflammatory mediators such as TNF-α and IL-6.
- Facilitates research into autoimmune regulation, macrophage activity, and immune-neuroendocrine crosstalk.
- Serves as a tool for characterizing anti-inflammatory peptide signaling within the adaptive and innate immune systems.
Pulmonary and Respiratory Pathway Research
- Investigated for its ability to influence airway smooth-muscle tone, mucosal secretion, and bronchial dilation through cAMP-dependent signaling pathways.
- Provides insight into how VIP receptor agonism affects respiratory smooth-muscle relaxation in pre-clinical and ex-vivo models.
Gastrointestinal and Digestive System Studies
- Utilized to study intestinal secretion, motility, and enteric nervous system communication.
- Supports investigation into neuropeptide control of gut motility and electrolyte transport.
- Acts as a key experimental peptide for mapping gut–brain axis interactions and enteric immune modulation.
Circadian Rhythm and Endocrine Research
- VIP is integral to maintaining circadian clock synchronization within the suprachiasmatic nucleus (SCN) of the hypothalamus.
- Enables researchers to explore hormonal rhythm entrainment, light-responsive peptide signaling, and endocrine homeostasis.
Cellular Receptor Mechanism Studies
- Binds primarily to VPAC1, VPAC2, and PAC1 receptors, activating adenylyl cyclase and increasing intracellular cAMP.
- Useful for mapping GPCR (G-protein–coupled receptor) structure–function relationships and signal transduction pathways.
This product is supplied strictly for laboratory research use only. It is not a drug, food, or cosmetic and must not be administered to humans or animals. Proper handling procedures and safety protocols should be followed by trained professionals when working with this material.
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Any references to specific peptides, studies, or potential biological functions are provided strictly for informational and educational purposes. Such content must not be considered medical, health, or legal advice, nor encouragement for non-research use.
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